Researchers map how Alzheimer’s pathology spreads across brain networks

Create a Profile

First Name(Required)

Last Name(Required)

Location Preference(Required)

Phone*(Required)

Email Address*(Required)

Gender

Conditions*(Required)

Race / Ethnicity

Contact Preferences(Required)

I accept digital forms of communication(Required)

I confirm that (1) the name and contact information set forth above is my name and contact information or that I am submitting the form on behalf of an individual who has legally authorized me to submit this request; (2) the personal information I provide in this form may be used by Accel Research Sites, and its affiliates, partners, and medical professionals in connection with considering my potential participation in clinical research studies; (3) I am requesting that Accel Research Sites contact me using the information I have provided on Accel Research Sites’ website; and (4) I have read and understand Accel Research Sites’ Privacy Policy.

CAPTCHA

Hidden

UTM Source

Hidden

UTM Campaign

Name

This field is for validation purposes and should be left unchanged.

Create a Profile

First Name(Required)

Last Name(Required)

Location Preference*(Required)

Phone*(Required)

Email Address*(Required)

Gender

Conditions of Interest*(Required)

Race / Ethnicity

Contact Preferences*(Required)

I accept digital forms of communication(Required)

CAPTCHA

Hidden

UTM Source

Hidden

UTM Campaign

This field is for validation purposes and should be left unchanged.

Get In Touch Mobile

Name(Required)

Last Name(Required)

Phone

Email(Required)

Reason for Contact(Required)

Enter additional message or questions(Required)

I accept digital forms of communication(Required)

I confirm that the name and contact information set forth above is my name and contact information or that I am submitting the form on behalf of an individual who has legally authorized me to submit this request; (2) the personal information I provide in this form may be used by Accel Research Sites, and its affiliates, partners, and medical professionals in connection with considering my potential participation in clinical research studies; (3) I am requesting that Accel Research Sites contact me using the information I have provided on Accel Research Sites’ website; and (4) I have read and understand Accel Research Sites’ Privacy Policy.

CAPTCHA

Name

This field is for validation purposes and should be left unchanged.

FIND A TRIAL NEAR YOU

-- or --

Select City No location found for this Location

FIND A TRIAL NEAR YOU

-- or --

Select City No location found for this Location

Back

Date Published: 12/12/2018

Researchers map how Alzheimer’s pathology spreads across brain networks

Improved technology makes possible for intensive, side-by-side comparisons of how tau and beta-amyloid spread in the brain in distinctive patterns.

Using this technology, researchers were able to reveal nuances into how, even in disease, the brain follows a dynamic and complex network of circuits and connections. The results were reported in the Oct. 29 issue of Nature Medicine.

The study was led by Dr. Jorge Sepulcre and Dr. Keith Johnson of The Gordon Center for Medical Imaging at Massachusetts General Hospital and Harvard Medical School, and Dr. Reisa Sperling, director of the Center for Alzheimer Research and Treatment at the Brigham and Women’s Hospital and professor of Neurology at Harvard Medical School. The team used data from the Harvard Aging Brain Study and the Allen Human Brain Atlas.

In a brain with Alzheimer’s disease, abnormal deposits of tau and beta-amyloid do not randomly appear, but instead show unique spatial patterns that follow the brain’s existing connected neural networks. To better understand how tau and beta-amyloid interact with and influence each other, the researchers looked closely at 3-D brain network and gene maps and found that both tau and beta-amyloid were associated with genes devoted to lipid metabolism, and that the APOE E4 gene – a risk factor for Alzheimer’s disease – played a central role in the relationships of these genetic networks.

The scientists found common genetic background for the malfunction of both proteins. The findings showed that in addition to APOE, other variations in genetic pathways shared by tau and beta-amyloid could trigger their accumulation. The study also found that tau propagation was associated with an axon-related (parts of neurons that pass messages away from the cell body) genetic profile, while beta-amyloid’s spread was connected with a dendrite-related (parts of neurons that receive messages from other cells) genetic profile.

The researchers hope this new understanding of tau and beta-amyloid’s propagation patterns can be combined with a person’s genetic profile to help develop precision medicine approaches for improved diagnosis, monitoring and therapies for Alzheimer’s disease in the brain.

This research was funded in part by NIH grants K23EB019023, T32EB013180, R01HL137230, R01-AG027435-S1, P50-AG00513421, R01AG046396, P01-AG036694 and 1RF1AG052653-01A1.

Reference: Sepulcre J et al. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine. 2018 Oct 29 doi: 10.1038/s41591-018-0206-4. [Epub ahead of print]

Source: https://www.nia.nih.gov/news/researchers-map-how-alzheimers-pathology-spreads-across-brain-networks

Back

Articles